Effect of Vinpocetine on Cerebral Blood Flow in Patients with Cerebrovascular Disorders 

Norihiko Tamaki M.D., Tadaki Kusunoki M.D., Satoshi Matsumoto M.D.

Department of Neurosurgery.
 Kobe University School of Medicine.
Kobe, Japan
Advances in therapy 1985; 2:53-6

Abstract

The 133xenon inhalation method was used in an open-label clinical trial to examine changes in cerebral blood flow (CBF) after vinpocetine treatment in 13 patients with cerebrovascular disorders. In all patients, measurement of regional cerebral blood flow (RCBF) was made prior to and after treatment with vinpocetine 5 mg t.i.d. for five to seven weeks. In ten of the patients, treatment was continued for a total of 8 to 16 weeks with an additional RCBF measurement at the end of their treatment. 
The results showed a significant increase in the Initial Slope Index (ISI) values of mean total CBF, and RCBF for the involved hemisphere after six weeks of treatment with vinpocetine.  The CBF for the involved lobe was significantly increased for ISI and flow rate of gray matter at six weeks and at the end of treatment.  No adverse reactions were reported.

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   1.   vinpocetine  treatment in acute stroke
   2.   vinpocetine  redistributes cerebral blood flow in post-stroke patients
   3.   vinpocetine  cerebral effects on stroke patients
   4.   vinpocetine  mechanism of action
   5.   vinpocetine  increases cerebral blood flow in stroke patients 
   6.   vinpocetine  in the treatment of cerebrovascular disorders
   7.   vinpocetine  as a free radical scavenger
   8.   vinpocetine  safety
   9.   vinpocetine  treatment for vascular senile cerebral dysfunction
 10.   vinpocetine  safety and efficacy
 11.   vinpocetine  improved visual acuity in 88% of subjects
 12.   vinpocetine  is indicated in ischemic disorders of cerebral circulation
 13.   vinpocetine  might increase adaptation to hypoxia
 14.   vinpocetine  use in dementia
 15.   vinpocetine  significantly reduced neuronal cell loss
 16.   vinpocetine  caused significant and quick improvement in vascular diseases
 17.   vinpocetine  increases cerebral blood flow
 18.   vinpocetine  enhances the glycolytic and oxidative glucose breakdown in CNS
 19.   vinpocetine  increases regional cerebral blood flow
 20.   vinpocetine  enhances oxygen release in vascular dementia 
 21.   vinpocetine  has a protective effect against cerebral ischemia
 22.   vinpocetine  improvemed red blood cell deformability in stroke patients
 23.   vinpocetine  study of patients with cerebrovascular disorders
 24.   vinpocetine  improved 87% of patients with central nervous system disorders
 25.   vinpocetine  significantly improved memory
 26.   vinpocetine  dose of 5mg caused increased cerebral blood flow
 27.   vinpocetine  might prove effective in augmenting cerebral blood flow
 28.   vinpocetine  was associated with improvement in short-term memory
 29.   vinpocetine  significant improvement in short-term memory test

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