The Efficacy and Safety of Vinpocetine in the Treatment of Patients with Chronic Vascular or Degenerative Senile Cerebral Dysfunction 

Marino Peruzza, M.D., Maurizio Dejacobis, M.D.

 Uníversity of Pavia. 
G.B. Glustinian Regional Hospital. Venice, Italy
Advances in therapy 1986; 4:201-4

Abstract

In a double-blind clinical trial, 22 elderly patients with cerebrovascular and central nervous system degenerative disorders were treated with vinpocetine, a synthetic ethyl ester of apovincamine.  They received 10 mg vinpocetine t.i.d. for 30 days, then 5 mg t.i.d. for 60 days. Matching placebo tablets were given to another 20 elderly patients for the 90-day trial period.  Patients on vinpocetine scored consistently better in all evaluations of the effectiveness of treatment including measurements on the Clinical Global Impressions 
and Sandoz Clinical Assessment-Geriatric Seales and the Mini-Mental Status Questionnaire. No serious side effects were related to the treatment drug.

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   1.   vinpocetine  treatment in acute stroke
   2.   vinpocetine  redistributes cerebral blood flow in post-stroke patients
   3.   vinpocetine  cerebral effects on stroke patients
   4.   vinpocetine  mechanism of action
   5.   vinpocetine  increases cerebral blood flow in stroke patients 
   6.   vinpocetine  in the treatment of cerebrovascular disorders
   7.   vinpocetine  as a free radical scavenger
   8.   vinpocetine  safety
   9.   vinpocetine  treatment for vascular senile cerebral dysfunction
 10.   vinpocetine  safety and efficacy
 11.   vinpocetine  improved visual acuity in 88% of subjects
 12.   vinpocetine  is indicated in ischemic disorders of cerebral circulation
 13.   vinpocetine  might increase adaptation to hypoxia
 14.   vinpocetine  use in dementia
 15.   vinpocetine  significantly reduced neuronal cell loss
 16.   vinpocetine  caused significant and quick improvement in vascular diseases
 17.   vinpocetine  increases cerebral blood flow
 18.   vinpocetine  enhances the glycolytic and oxidative glucose breakdown in CNS
 19.   vinpocetine  increases regional cerebral blood flow
 20.   vinpocetine  enhances oxygen release in vascular dementia 
 21.   vinpocetine  has a protective effect against cerebral ischemia
 22.   vinpocetine  improvemed red blood cell deformability in stroke patients
 23.   vinpocetine  study of patients with cerebrovascular disorders
 24.   vinpocetine  improved 87% of patients with central nervous system disorders
 25.   vinpocetine  significantly improved memory
 26.   vinpocetine  dose of 5mg caused increased cerebral blood flow
 27.   vinpocetine  might prove effective in augmenting cerebral blood flow
 28.   vinpocetine  was associated with improvement in short-term memory
 29.   vinpocetine  significant improvement in short-term memory test

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